The holy hierarch raised Acacius with love, made him a reader, and then ordained him a deacon and then to the holy priesthood. Saint Acacius devoutly served the Church. He instructed both adults and children in the Holy Scripture, and in the Orthodox Confession of faith.
Among his disciples was Saint Euthymius the Great (January 20).
After the death of Saint Ostrychius, Saint Acacius was elevated to the bishop’s throne of Melitene by general acclamation. He wisely governed his diocese. By his firm faith, humility and deeds, the saint acquired the gift of wonderworking. Once, during a dry summer, the saint celebrated Liturgy in an open field, suddenly the wine in the Holy Chalice was mixed by the falling rain, which fell throughout the land.
He prayed during a flood, and the advancing river turned away and did not rise higher than the stone which he had placed at the riverbank. On one of the islands of the River Azar, despite the opposition of the pagans, the saint built a temple in honor of the Most Holy Theotokos. The builders of the church either through carelessness or through malice, were not careful in building the dome. During the Liturgy the dome was ready to collapse. The people rushed out of the church in terror. But the saint halted their flight saying, “The Lord is the defender of my life, of whom shall I be afraid?” (Ps. 26/27:1). The dome remained suspended in the air. Only when the services were ended, and the saint was the last one to emerge from the church, did the dome collapse, causing harm to no one. After this, the church was rebuilt.
Saint Acacius participated in the Third Ecumenical Council (431) and he defended the Orthodox teaching of the Two Natures (Divine and Human) of the Savior, and of His seedless Birth from the Most Holy Virgin Mother of God.
Saint Acacius peacefully fell asleep in the Lord around the year 435. He should not be confused with Saint Acacius the Confessor (March 31), who was also a bishop of Melitene.